Genomic diversity of Yersinia pestis from Yunnan Province, China, implies a potential common ancestor as the source of two plague epidemics

Author:

Qin Jingliang,Wu YarongORCID,Shi Liyuan,Zuo Xiujuan,Zhang Xianglilan,Qian Xiuwei,Fan Hang,Guo Yan,Cui Mengnan,Zhang Haipeng,Yang Fengyi,Kong Jinjiao,Song YajunORCID,Yang RuifuORCID,Wang PengORCID,Cui YujunORCID

Abstract

AbstractPlague, caused by Yersinia pestis, is a zoonotic disease that can reemerge and cause outbreaks following decades of latency in natural plague foci. However, the genetic diversity and spread pattern of Y. pestis during these epidemic-silent cycles remain unclear. In this study, we analyze 356 Y. pestis genomes isolated between 1952 and 2016 in the Yunnan Rattus tanezumi plague focus, China, covering two epidemic-silent cycles. Through high-resolution genomic epidemiological analysis, we find that 96% of Y. pestis genomes belong to phylogroup 1.ORI2 and are subdivided into two sister clades (Sublineage1 and Sublineage2) characterized by different temporal-spatial distributions and genetic diversity. Most of the Sublineage1 strains are isolated from the first epidemic-silent cycle, while Sublineage2 strains are predominantly from the second cycle and revealing a west to east spread. The two sister clades evolved in parallel from a common ancestor and independently lead to two separate epidemics, confirming that the pathogen responsible for the second epidemic following the silent interval is not a descendant of the causative strain of the first epidemic. Our results provide a mechanism for defining epidemic-silent cycles in natural plague foci, which is valuable in the prevention and control of future plague outbreaks.

Funder

State Key Laboratory of Pathogen and Biosecurity

National Natural Science Foundation of China

Key Bio-safety Research and Development Technology Project

Publisher

Springer Science and Business Media LLC

Subject

General Agricultural and Biological Sciences,General Biochemistry, Genetics and Molecular Biology,Medicine (miscellaneous)

Cited by 3 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Epidemiological Situation on Plague around the World. Forecast of Epizootic Activity of Natural Plague Foci in the Russian Federation for 2024;Problems of Particularly Dangerous Infections;2024-04-02

2. The Evolutionary History of Yersinia pestis;Birkhäuser Advances in Infectious Diseases;2024

3. The Ecology of Plague;Birkhäuser Advances in Infectious Diseases;2024

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