Fronto-thalamic networks and the left ventral thalamic nuclei play a key role in aphasia after thalamic stroke

Author:

Rangus IdaORCID,Rios Ana SofiaORCID,Horn Andreas,Fritsch Merve,Khalil AhmedORCID,Villringer Kersten,Udke Birgit,Ihrke ManuelaORCID,Grittner UlrikeORCID,Galinovic Ivana,Al-Fatly BassamORCID,Endres Matthias,Kufner AnnaORCID,Nolte Christian H.ORCID

Abstract

AbstractThalamic aphasia results from focal thalamic lesions that cause dysfunction of remote but functionally connected cortical areas due to language network perturbation. However, specific local and network-level neural substrates of thalamic aphasia remain incompletely understood. Using lesion symptom mapping, we demonstrate that lesions in the left ventrolateral and ventral anterior thalamic nucleus are most strongly associated with aphasia in general and with impaired semantic and phonemic fluency and complex comprehension in particular. Lesion network mapping (using a normative connectome based on fMRI data from 1000 healthy individuals) reveals a Thalamic aphasia network encompassing widespread left-hemispheric cerebral connections, with Broca’s area showing the strongest associations, followed by the superior and middle frontal gyri, precentral and paracingulate gyri, and globus pallidus. Our results imply the critical involvement of the left ventrolateral and left ventral anterior thalamic nuclei in engaging left frontal cortical areas, especially Broca’s area, during language processing.

Publisher

Springer Science and Business Media LLC

Cited by 1 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Subcortical Aphasia: An Update;Current Neurology and Neuroscience Reports;2024-09-11

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