Abstract
AbstractHow global and local activity interact with each other is a common question in complex systems like climate and economy. Analogously, the brain too displays ‘global’ activity that interacts with local-regional activity and modulates behavior. The brain’s global activity, investigated as global signal in fMRI, so far, has mainly been conceived as non-neuronal noise. We here review the findings from healthy and clinical populations to demonstrate the neural basis and functions of global signal to brain and behavior. We show that global signal (i) is closely coupled with physiological signals and modulates the arousal level; and (ii) organizes an elaborated dynamic topography and coordinates the different forms of cognition. We also postulate a Dual-Layer Model including both background and surface layers. Together, the latest evidence strongly suggests the need to go beyond the view of global signal as noise by embracing a dual-layer model with background and surface layer.
Publisher
Springer Science and Business Media LLC
Subject
General Agricultural and Biological Sciences,General Biochemistry, Genetics and Molecular Biology,Medicine (miscellaneous)
Reference121 articles.
1. Bindoff, N. L. et al. Detection and attribution of climate change: from global to regional. (2013).
2. Oppenheimer, M. et al. in Climate Change 2014 Impacts, Adaptation and Vulnerability: Part A: Global and Sectoral Aspects 1039–1100 (Cambridge University Press, 2015).
3. Rodrik, D. One economics, many recipes: globalization, institutions, and economic growth. (Princeton University Press, 2008).
4. Goldberg, P. K. & Pavcnik, N. Distributional effects of globalization in developing countries. J. Econ. Lit. 45, 39–82 (2007).
5. Conio, B. et al. Opposite effects of dopamine and serotonin on resting-state networks: review and implications for psychiatric disorders. Mol. Psychiatry 25, 82–93 (2020).
Cited by
14 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献