Artemisinin resistance in the malaria parasite, Plasmodium falciparum, originates from its initial transcriptional response-Reference-Cited by-同舟云学术

Artemisinin resistance in the malaria parasite, Plasmodium falciparum, originates from its initial transcriptional response

Published:2022-03-28 Issue:1 Volume:5 Page:
ISSN:2399-3642
Container-title:Communications Biology
language:en
Short-container-title:Commun Biol

Author:

Zhu Lei,van der Pluijm Rob W.,Kucharski Michal^ORCID,Nayak Sourav,Tripathi Jaishree,White Nicholas J.,Day Nicholas P. J.,Faiz Abul,Phyo Aung Pyae^ORCID,Amaratunga Chanaki,Lek Dysoley,Ashley Elizabeth A.^ORCID,Nosten François^ORCID,Smithuis Frank,Ginsburg Hagai,von Seidlein Lorenz,Lin Khin,Imwong Mallika,Chotivanich Kesinee,Mayxay Mayfong,Dhorda Mehul,Nguyen Hoang Chau,Nguyen Thuy Nhien Thanh,Miotto Olivo^ORCID,Newton Paul N.,Jittamala Podjanee,Tripura Rupam,Pukrittayakamee Sasithon,Peto Thomas J.^ORCID,Hien Tran Tinh,Dondorp Arjen M.^ORCID,Bozdech Zbynek^ORCID

Abstract

AbstractThe emergence and spread of artemisinin-resistant Plasmodium falciparum, first in the Greater Mekong Subregion (GMS), and now in East Africa, is a major threat to global malaria elimination ambitions. To investigate the artemisinin resistance mechanism, transcriptome analysis was conducted of 577 P. falciparum isolates collected in the GMS between 2016–2018. A specific artemisinin resistance-associated transcriptional profile was identified that involves a broad but discrete set of biological functions related to proteotoxic stress, host cytoplasm remodelling, and REDOX metabolism. The artemisinin resistance-associated transcriptional profile evolved from initial transcriptional responses of susceptible parasites to artemisinin. The genetic basis for this adapted response is likely to be complex.

Funder

Wellcome Trust

Ministry of Health -Singapore

Ministry of Education - Singapore

Publisher

Springer Science and Business Media LLC

Subject

General Agricultural and Biological Sciences,General Biochemistry, Genetics and Molecular Biology,Medicine (miscellaneous)

Link

https://www.nature.com/articles/s42003-022-03215-0.pdf

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