Three doses of BNT162b2 vaccine confer neutralising antibody capacity against the SARS-CoV-2 Omicron variant

Author:

Ariën Kevin K.ORCID,Heyndrickx Leo,Michiels Johan,Vereecken Katleen,Van Lent Kurt,Coppens Sandra,Willems Betty,Pannus PieterORCID,Martens Geert A.ORCID,Van Esbroeck MarjanORCID,Goossens Maria E.,Marchant Arnaud,Bartholomeeusen Koen,Desombere Isabelle

Abstract

AbstractWe report the levels of neutralising antibodies against Wuhan, Delta and Omicron variants in unimmunized infected (group 1), immunised and boosted (group 2) and infected immunised and boosted (group 3) adult individuals. Our observations support the rapid administration of a booster vaccine dose to prevent infection and disease caused by Omicron.

Funder

Research Foundation Flanders

Belgian Federal Government through Sciensano

Publisher

Springer Science and Business Media LLC

Subject

Pharmacology (medical),Infectious Diseases,Pharmacology,Immunology

Reference13 articles.

1. Viana, R. et al. Rapid epidemic expansion of the SARS-CoV-2 Omicron variant in southern Africa. Nature. https://doi.org/10.1038/s41586-022-04411-y (2022).

2. Pulliam, J. R. C. et al. Increased risk of SARS-CoV-2 reinfection associated with emergence of the Omicron variant in South Africa. Preprint at https://www.medrxiv.org/content/10.1101/2021.11.11.21266068v2.

3. Aggarwal, A. et al. SARS-CoV-2 Omicron: evasion of potent humoral responses and resistance to clinical immunotherapeutics relative to viral variants of concern. Preprint at https://www.medrxiv.org/content/10.1101/2021.12.14.21267772v1.

4. Cele, S. et al. Omicron extensively but incompletely escapes Pfizer BNT162b2 neutralization. Nature. https://doi.org/10.1038/s41586-021-04387-1 (2021).

5. Rössler, A., Riepler, L., Bante, D., von Laer, D. & Kimpel, J. SARS-CoV-2 Omicron variant neutralization in serum from vaccinated and convalescent persons. N Engl J Med. https://doi.org/10.1056/NEJMc2119236 (2022).

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