A therapeutic hepatitis B mRNA vaccine with strong immunogenicity and persistent virological suppression-Reference-Cited by-同舟云学术

A therapeutic hepatitis B mRNA vaccine with strong immunogenicity and persistent virological suppression

Published:2024-02-03 Issue:1 Volume:9 Page:
ISSN:2059-0105
Container-title:npj Vaccines
language:en
Short-container-title:npj Vaccines

Author:

Zhao Huajun^ORCID,Shao Xianyu,Yu Yating,Huang Lulu,Amor Narh Philip,Guo Kun,Weng Changzhen,Zhao Weijun,Yang Ailu,Hu Jiesen,Yang Hongbao,Liu Zhenguang,Han Qiuju,Shi Leilei,Sun Shiyu,Zhang Jian^ORCID,Lin Ang^ORCID,Yang Yong^ORCID

Abstract

AbstractHere we report on the development and comprehensive evaluations of an mRNA vaccine for chronic hepatitis B (CHB) treatment. In two different HBV carrier mouse models generated by viral vector-mediated HBV transfection (pAAV-HBV1.2 and rAAV8-HBV1.3), this vaccine demonstrates sufficient and persistent virological suppression, and robust immunogenicity in terms of induction of strong innate immune activation, high-level virus-specific antibodies, memory B cells and T cells. mRNA platform therefore holds prospects for therapeutic vaccine development to combat CHB.

Publisher

Springer Science and Business Media LLC

Link

https://www.nature.com/articles/s41541-024-00813-3.pdf

Reference26 articles.

1. World Health Organization. Global progress report on HIV, viral hepatitis and sexually transmitted infections (WHO, 2021).

2. Grossi, G., Vigano, M., Loglio, A. & Lampertico, P. Hepatitis B virus long-term impact of antiviral therapy nucleot(s)ide analogues (NUCs). Liver Int 37, 45–51 (2017).

3. Konerman, M. A. & Lok, A. S. Interferon Treatment for Hepatitis B. Clin. Liver Dis. 20, 645–665 (2016).

4. Wang, J., Gujar, S. A., Cova, L. & Michalak, T. I. Bicistronic woodchuck hepatitis virus core and gamma interferon DNA vaccine can protect from hepatitis but does not elicit sterilizing antiviral immunity. J. Virol. 81, 903–916 (2007).

5. Martin, P. et al. TG1050, an immunotherapeutic to treat chronic hepatitis B, induces robust T cells and exerts an antiviral effect in HBV-persistent mice. Gut 64, 1961–1971 (2015).

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