A Rift Valley fever virus Gn ectodomain-based DNA vaccine induces a partial protection not improved by APC targeting-Reference-Cited by-同舟云学术

A Rift Valley fever virus Gn ectodomain-based DNA vaccine induces a partial protection not improved by APC targeting

Published:2018-04-20 Issue:1 Volume:3 Page:
ISSN:2059-0105
Container-title:npj Vaccines
language:en
Short-container-title:npj Vaccines

Author:

Chrun Tiphany,Lacôte Sandra,Urien Céline,Jouneau Luc,Barc Céline,Bouguyon Edwige,Contreras Vanessa,Ferrier-Rembert Audrey,Peyrefitte Christophe N.,Busquets Nuria,Vidal Enric,Pujols Joan,Marianneau Philippe,Schwartz-Cornil Isabelle

Publisher

Springer Science and Business Media LLC

Subject

Pharmacology (medical),Infectious Diseases,Pharmacology,Immunology

Link

http://www.nature.com/articles/s41541-018-0052-x.pdf

Reference61 articles.

1. Pepin, M., Bouloy, M., Bird, B., Kemp, A. & Paweska, J. Rift Valley fever virus (Bunyaviridae: Phlebovirus): an update on pathogenesis, molecular epidemiology, vectors, diagnostics and prevention. Vet. Res. 41, 61–66 (2010).

2. Schmaljohn, C. S. et al. Baculovirus expression of the M genome segment of Rift Valley fever virus and examination of antigenic and immunogenic properties of the expressed proteins. Virology 170, 184–192 (1989).

3. Wu, Y. et al. Structures of phlebovirus glycoprotein Gn and identification of a neutralizing antibody epitope. Proc. Natl Acad. Sci. USA 114, E7564–E7573 (2017).

4. Besselaar, T. G. & Blackburn, N. K. Topological mapping of antigenic sites on the Rift Valley fever virus envelope glycoproteins using monoclonal antibodies. Arch. Virol. 121, 111–124 (1991).

5. de Boer, S. M. et al. Rift Valley fever virus subunit vaccines confer complete protection against a lethal virus challenge. Vaccine 28, 2330–2339 (2010).

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