The codon 72 polymorphic variants of p53 have markedly different apoptotic potential
Author:
Publisher
Springer Science and Business Media LLC
Subject
Genetics
Link
http://www.nature.com/articles/ng1093z.pdf
Reference36 articles.
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3. Caelles, C., Helmberg, A. & Karin, M. p53-dependent apoptosis in the absence of transcriptional activation of p53-target genes. Nature 370, 220–223 (1994).
4. Wagner, A.J., Kokontis, J.M. & Hay, N. Myc-mediated apoptosis requires wild-type p53 in a manner independent of cell cycle arrest and the ability of p53 to induce p21waf1/cip1. Genes Dev. 8, 2817–2830 (1994).
5. Koumenis, C. et al. Regulation of p53 by hypoxia: dissociation of transcriptional repression and apoptosis from p53-dependent transactivation. Mol. Cell. Biol. 21, 1297–1310 (2001).
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