Fumarate is an epigenetic modifier that elicits epithelial-to-mesenchymal transition-Reference-Cited by-同舟云学术

Fumarate is an epigenetic modifier that elicits epithelial-to-mesenchymal transition

Published:2016-08-31 Issue:7621 Volume:537 Page:544-547
ISSN:0028-0836
Container-title:Nature
language:en
Short-container-title:Nature

Author:

Sciacovelli Marco,Gonçalves Emanuel,Johnson Timothy Isaac,Zecchini Vincent Roberto,da Costa Ana Sofia Henriques,Gaude Edoardo,Drubbel Alizee Vercauteren,Theobald Sebastian Julian,Abbo Sandra Riekje,Tran Maxine Gia Binh,Rajeeve Vinothini,Cardaci Simone,Foster Sarah,Yun Haiyang,Cutillas Pedro,Warren Anne,Gnanapragasam Vincent,Gottlieb Eyal,Franze Kristian,Huntly Brian,Maher Eamonn Richard,Maxwell Patrick Henry,Saez-Rodriguez Julio,Frezza Christian

Publisher

Springer Science and Business Media LLC

Subject

Multidisciplinary

Link

http://www.nature.com/articles/nature19353.pdf

Reference40 articles.

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3. Yang, M., Soga, T., Pollard, P. J. & Adam, J. The emerging role of fumarate as an oncometabolite. Front Oncol. 2, 85 (2012)

4. Laukka, T. et al. Fumarate and succinate regulate expression of hypoxia-inducible genes via TET enzymes. J. Biol. Chem. 291, 4256–4265 (2016)

5. Xiao, M. et al. Inhibition of α-KG-dependent histone and DNA demethylases by fumarate and succinate that are accumulated in mutations of FH and SDH tumor suppressors. Genes Dev. 26, 1326–1338 (2012)

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