Fungal indole alkaloid biogenesis through evolution of a bifunctional reductase/Diels

Fungal indole alkaloid biogenesis through evolution of a bifunctional reductase/Diels–Alderase

Published:2019-09-23 Issue:11 Volume:11 Page:972-980
ISSN:1755-4330
Container-title:Nature Chemistry
language:en
Short-container-title:Nat. Chem.

Author:

Dan Qingyun^ORCID,Newmister Sean A.^ORCID,Klas Kimberly R.^ORCID,Fraley Amy E.,McAfoos Timothy J.,Somoza Amber D.,Sunderhaus James D.,Ye Ying,Shende Vikram V.,Yu Fengan,Sanders Jacob N.,Brown W. Clay,Zhao Le,Paton Robert S.^ORCID,Houk K. N.,Smith Janet L.^ORCID,Sherman David H.^ORCID,Williams Robert M.

Publisher

Springer Science and Business Media LLC

Subject

General Chemical Engineering,General Chemistry

Link

http://www.nature.com/articles/s41557-019-0326-6.pdf

Reference37 articles.

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2. Klas, K., Tsukamoto, S., Sherman, D. H. & Williams, R. M. Natural Diels–Alderases: elusive and irresistable. J. Org. Chem. 80, 11672–11685 (2015).

3. Klas, K. R. et al. Structural and stereochemical diversity in prenylated indole alkaloids containing the bicyclo[2.2.2]diazaoctane ring system from marine and terrestrial fungi. Nat. Prod. Rep. 35, 532–558 (2018).

4. Robertson, A. P. et al. Paraherquamide and 2-deoxy-paraherquamide distinguish cholinergic receptor subtypes in ascaris muscle. J. Pharmacol. Exp. Ther. 303, 853–860 (2002).

5. Little, P. R. et al. Efficacy of a combined oral formulation of derquantel–abamectin against the adult and larval stages of nematodes in sheep, including anthelmintic-resistant strains. Vet. Parasitol. 181, 180–193 (2011).

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