Abstract
AbstractBacterial infection and the growth of antibiotic resistance is a serious problem that leads to patient suffering, death and increased costs of healthcare. To address this problem, we propose using flexible organic light-emitting diodes (OLEDs) as light sources for photodynamic therapy (PDT) to kill bacteria. PDT involves the use of light and a photosensitizer to generate reactive oxygen species that kill neighbouring cells. We have developed flexible top-emitting OLEDs with the ability to tune the emission peak from 669 to 737 nm to match the photosensitizer, together with high irradiance, low driving voltage, long operational lifetime and adequate shelf-life. These features enable OLEDs to be the ideal candidate for ambulatory PDT light sources. A detailed study of OLED–PDT for killingStaphylococcus aureuswas performed. The results show that our OLEDs in combination with the photosensitizer methylene blue, can kill more than 99% of bacteria. This indicates a huge potential for using OLEDs to treat bacterial infections.
Publisher
Springer Science and Business Media LLC
Subject
Electrical and Electronic Engineering,General Materials Science
Reference39 articles.
1. Luepke, K. H. et al. Past, present, and future of antibacterial economics: increasing bacterial resistance, limited antibiotic pipeline, and societal implications. Pharmacother. J. Hum. Pharmacol. Drug Ther. 37, 71–84 (2017).
2. Laxminarayan, R. et al. Antibiotic resistance-the need for global solutions. Lancet Infect. Dis. 13, 1057–1098 (2013).
3. Renwick, M. J., Simpkin, V. & Mossialos, E. Targeting innovation in antibiotic drug discovery and development: the need for a one-health, one-Europe, one-world framwork. European Observatory on Health Systems and Policies, London, UK, Health Policy Series No. 45, 1–133, ISBN 9789289050401 (2016).
4. Laxminarayan, R. et al. Access to effective antimicrobials: a worldwide challenge. Lancet 387, 168–175 (2016).
5. O’Neill, J. Tackling Drug-Resistant Infections Globally: Final Report and Recommendations (Review on Antimicrobial Resistance, 2016); http://amr-review.org/sites/default/files/160525_Final%20paper_with%20cover.pdf
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