Paediatric and adult glioblastoma: multiform (epi)genomic culprits emerge

Author:

Sturm Dominik,Bender Sebastian,Jones David T. W.,Lichter Peter,Grill Jacques,Becher Oren,Hawkins Cynthia,Majewski Jacek,Jones Chris,Costello Joseph F.,Iavarone Antonio,Aldape Kenneth,Brennan Cameron W.,Jabado Nada,Pfister Stefan M.

Publisher

Springer Science and Business Media LLC

Subject

General Earth and Planetary Sciences,General Environmental Science

Reference224 articles.

1. Louis, D. N., Ohgaki, H., Wiestler, O. D. & Cavenee, W. K. WHO Classification of Tumors of the Central Nervous System (International Agency for Research on Cancer, 2007).

2. Dolecek, T., Propp, J., Stroup, N. & Kruchko, C. CBTRUS statistical report: primary brain and central nervous system tumors diagnosed in the United States in 2005–2009. Neuro Oncol. 14 (Suppl. 5), 49 (2012).

3. Ohgaki, H. & Kleihues, P. Genetic pathways to primary and secondary glioblastoma. Am. J. Pathol. 170, 1445–1453 (2007).

4. Puget, S. et al. Mesenchymal transition and PDGFRA amplification/mutation are key distinct oncogenic events in pediatric diffuse intrinsic pontine gliomas. PLoS ONE 7, e30313 (2012).

5. Khuong-Quang, D. A. et al. K27M mutation in histone H3.3 defines clinically and biologically distinct subgroups of pediatric diffuse intrinsic pontine gliomas. Acta Neuropathol. 124, 439–447 (2012).

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