Variant-aware saturating mutagenesis using multiple Cas9 nucleases identifies regulatory elements at trait-associated loci-Reference-Cited by-同舟云学术

Variant-aware saturating mutagenesis using multiple Cas9 nucleases identifies regulatory elements at trait-associated loci

Published:2017-02-20 Issue:4 Volume:49 Page:625-634
ISSN:1061-4036
Container-title:Nature Genetics
language:en
Short-container-title:Nat Genet

Author:

Canver Matthew C,Lessard Samuel,Pinello Luca,Wu Yuxuan,Ilboudo Yann,Stern Emily N,Needleman Austen J,Galactéros Frédéric,Brugnara Carlo,Kutlar Abdullah,McKenzie Colin,Reid Marvin,Chen Diane D,Das Partha Pratim,A Cole Mitchel,Zeng Jing,Kurita Ryo,Nakamura Yukio,Yuan Guo-Cheng,Lettre Guillaume,Bauer Daniel E,Orkin Stuart H

Publisher

Springer Science and Business Media LLC

Subject

Genetics

Link

http://www.nature.com/articles/ng.3793.pdf

Reference52 articles.

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2. Bauer, D.E. et al. An erythroid enhancer of BCL11A subject to genetic variation determines fetal hemoglobin level. Science 342, 253–257 (2013).

3. Canver, M.C. et al. BCL11A enhancer dissection by Cas9-mediated in situ saturating mutagenesis. Nature 527, 192–197 (2015).

4. Canver, M.C. et al. Characterization of genomic deletion efficiency mediated by clustered regularly interspaced palindromic repeats (CRISPR)/Cas9 nuclease system in mammalian cells. J. Biol. Chem. 289, 21312–21324 (2014).

5. Corradin, O. et al. Combinatorial effects of multiple enhancer variants in linkage disequilibrium dictate levels of gene expression to confer susceptibility to common traits. Genome Res. 24, 1–13 (2014).

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