Fusion of TTYH1 with the C19MC microRNA cluster drives expression of a brain-specific DNMT3B isoform in the embryonal brain tumor ETMR-Reference-Cited by-同舟云学术

Fusion of TTYH1 with the C19MC microRNA cluster drives expression of a brain-specific DNMT3B isoform in the embryonal brain tumor ETMR

Published:2013-12-08 Issue:1 Volume:46 Page:39-44
ISSN:1061-4036
Container-title:Nature Genetics
language:en
Short-container-title:Nat Genet

Author:

Kleinman Claudia L,Gerges Noha,Papillon-Cavanagh Simon,Sin-Chan Patrick,Pramatarova Albena,Quang Dong-Anh Khuong,Adoue Véronique,Busche Stephan,Caron Maxime,Djambazian Haig,Bemmo Amandine,Fontebasso Adam M,Spence Tara,Schwartzentruber Jeremy,Albrecht Steffen,Hauser Peter,Garami Miklos,Klekner Almos,Bognar Laszlo,Montes Jose-Luis,Staffa Alfredo,Montpetit Alexandre,Berube Pierre,Zakrzewska Magdalena,Zakrzewski Krzysztof,Liberski Pawel P,Dong Zhifeng,Siegel Peter M,Duchaine Thomas,Perotti Christian,Fleming Adam,Faury Damien,Remke Marc,Gallo Marco,Dirks Peter,Taylor Michael D,Sladek Robert,Pastinen Tomi,Chan Jennifer A,Huang Annie,Majewski Jacek,Jabado Nada

Publisher

Springer Science and Business Media LLC

Subject

Genetics

Link

http://www.nature.com/articles/ng.2849.pdf

Reference43 articles.

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2. Pfister, S. et al. Novel genomic amplification targeting the microRNA cluster at 19q13.42 in a pediatric embryonal tumor with abundant neuropil and true rosettes. Acta Neuropathol. 117, 457–464 (2009).

3. Yanagisawa, Y., Ito, E., Yuasa, Y. & Maruyama, K. The human DNA methyltransferases DNMT3A and DNMT3B have two types of promoters with different CpG contents. Biochim. Biophys. Acta 1577, 457–465 (2002).

4. Benetti, R. et al. A mammalian microRNA cluster controls DNA methylation and telomere recombination via Rbl2-dependent regulation of DNA methyltransferases. Nat. Struct. Mol. Biol. 15, 268–279 (2008).

5. Sinkkonen, L. et al. MicroRNAs control de novo DNA methylation through regulation of transcriptional repressors in mouse embryonic stem cells. Nat. Struct. Mol. Biol. 15, 259–267 (2008).

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