Therapeutic strategies targeting connexins
Author:
Publisher
Springer Science and Business Media LLC
Subject
Drug Discovery,Pharmacology,General Medicine
Link
http://www.nature.com/articles/nrd.2018.138.pdf
Reference298 articles.
1. Revel, J. P. & Karnovsky, M. J. Hexagonal array of subunits in intercellular junctions of the mouse heart and liver. J. Cell Biol. 33, C7–C12 (1967).
2. Sohl, G. & Willecke, K. Gap junctions and the connexin protein family. Cardiovasc. Res. 62, 228–232 (2004). This review describes the connexin gene family, including their structure.
3. Aasen, T., Mesnil, M., Naus, C. C., Lampe, P. D. & Laird, D. W. Gap junctions and cancer: communicating for 50 years. Nat. Rev. Cancer 16, 775–788 (2016). This is a comprehensive Review that summarizes the large body of work linking connexins, growth control and cancer.
4. Bruzzone, R., Hormuzdi, S. G., Barbe, M. T., Herb, A. & Monyer, H. Pannexins, a family of gap junction proteins expressed in brain. Proc. Natl Acad. Sci. USA 100, 13644–13649 (2003). Here, the authors demonstrate that pannexins have channel-forming properties.
5. Esseltine, J. L. & Laird, D. W. Next-generation connexin and pannexin cell biology. Trends Cell Biol. 26, 944–955 (2016).
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