Dose findings of antofloxacin hydrochloride for treating bacterial infections in an early clinical trial using PK-PD parameters in healthy volunteers

Author:

Li Yun-fei,Wang Kun,Yin Fang,He Ying-chun,Huang Ji-han,Zheng Qing-shan

Publisher

Springer Science and Business Media LLC

Subject

Pharmacology (medical),Pharmacology,General Medicine

Reference20 articles.

1. Ye H, Wu J, Yang Y, Chen K, Ji R . Antibacterial activities of the derivatives-YH54 and YH57 of levofloxacin in vitro. Chin Pharmacol Bull 2002; 18: 112–13.

2. Food and Drug Administration. Guidiance for industry: Population pharmacokinetics. U.S. department of healthy and human service 1999.

3. Lu Y, Kang ZS, Zhu Y, Zhang M, Liu Y, Li TY, et al. Pharmacokinetic study of single and multiple oral dose administration of antofloxacin hydrochloride in healthy male volunteers. Chin Med J 2011; 124: 242–5.

4. Wang J, Xiao Y, Lu Y, Kang Z, Zhang M, Liu Y, et al. Pharmacokinetics of antofloxacin hydrochloride in healthy male subjects after multiple intravenous dose administration. Xenobiotica 2011; 41: 561–6.

5. Xiao Y, Lu Y, Kang Z, Zhang M, Liu Y, Li T . Pharmacokinetics of antofloxacin hydrochloride, a new fluoroquinolone antibiotic, after single oral dose administration in Chinese healthy male volunteers. Biopharm Drug Dispos 2008; 29: 167–72.

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