Obsessive–compulsive symptoms in a large population-based twin-family sample are predicted by clinically based polygenic scores and by genome-wide SNPs

Author:

den Braber A,Zilhão N R,Fedko I O,Hottenga J-J,Pool RORCID,Smit D J A,Cath D C,Boomsma D I

Publisher

Springer Science and Business Media LLC

Subject

Biological Psychiatry,Cellular and Molecular Neuroscience,Psychiatry and Mental health

Reference35 articles.

1. American Psychiatric Association Diagnostic and Statistical Manual of Mental Disorder: DSM-IV, 4th edn, American Psychiatric Association: Washington, DC, 1994.

2. Ayuso Mateos JL . Global Burden of Obsessive-compulsive Disorder in the Year 2000. World Health Organization World Health Statistics: Geneva, Switzerland, 2006.

3. Taylor S . Etiology of obsessions and compulsions: a meta-analysis and narrative review of twin studies. Clin Psychol Rev 2011; 31: 1361–1372.

4. Mathews CA, Delucchi K, Cath DC, Willemsen G, Boomsma DI . Partitioning the etiology of hoarding and obsessive-compulsive symptoms. Psychol Med 2014; 44: 2867–2876.

5. Stewart SE, Yu D, Scharf JM, Neale BM, Fagerness JA, Mathews CA et al. Genome-wide association study of obsessive-compulsive disorder. Mol Psychiatry 2013; 18: 788–798.

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