The association of cytochrome P450 genetic polymorphisms with sulfolane formation and the efficacy of a busulfan-based conditioning regimen in pediatric patients undergoing hematopoietic stem cell transplantation

Author:

Uppugunduri C R S,Rezgui M A,Diaz P H,Tyagi A K,Rousseau J,Daali Y,Duval M,Bittencourt H,Krajinovic M,Ansari M

Publisher

Springer Science and Business Media LLC

Subject

Pharmacology,Genetics,Molecular Medicine

Reference43 articles.

1. Schattenberg AV, Levenga TH . Differences between the different conditioning regimens for allogeneic stem cell transplantation. Curr Opin Oncol 2006; 18: 667–670.

2. Czerwinski M, Gibbs JP, Slattery JT . Busulfan conjugation by glutathione S-transferases alpha, mu, and pi. Drug Metab Dispos 1996; 24: 1015–1019.

3. Cooper AJ, Younis IR, Niatsetskaya ZV, Krasnikov BF, Pinto JT, Petros WP et al. Metabolism of the cysteine S-conjugate of busulfan involves a beta-lyase reaction. Drug Metab Dispos 2008; 36: 1546–1552.

4. Hassan M, Oberg G, Ehrsson H, Ehrnebo M, Wallin I, Smedmyr B et al. Pharmacokinetic and metabolic studies of high-dose busulphan in adults. Eur J Clin Pharmacol 1989; 36: 525–530.

5. Malar R, Sjoo F, Rentsch K, Hassan M, Gungor T . Therapeutic drug monitoring is essential for intravenous busulfan therapy in pediatric hematopoietic stem cell recipients. Pediatr Transplant 2011; 15: 580–588.

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