Identification of small molecule inhibitors of anthrax lethal factor-Reference-Cited by-同舟云学术

Identification of small molecule inhibitors of anthrax lethal factor

Published:2003-12-29 Issue:1 Volume:11 Page:67-72
ISSN:1545-9993
Container-title:Nature Structural & Molecular Biology
language:en
Short-container-title:Nat Struct Mol Biol

Author:

Panchal Rekha G,Hermone Ann R,Nguyen Tam Luong,Wong Thiang Yian,Schwarzenbacher Robert,Schmidt James,Lane Douglas,McGrath Connor,Turk Benjamin E,Burnett James,Aman M Javad,Little Stephen,Sausville Edward A,Zaharevitz Daniel W,Cantley Lewis C,Liddington Robert C,Gussio Rick,Bavari Sina

Publisher

Springer Science and Business Media LLC

Subject

Molecular Biology,Structural Biology

Link

http://www.nature.com/articles/nsmb711.pdf

Reference25 articles.

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2. Scobie, H.M., Rainey, G.J., Bradley, K.A. & Young, J.A. Human capillary morphogenesis protein 2 functions as an anthrax toxin receptor. Proc. Natl. Acad. Sci. USA 100, 5170–5174 (2003).

3. Klimpel, K.R., Molloy, S.S., Thomas, G. & Leppla, S.H. Anthrax toxin protective antigen is activated by a cell surface protease with the sequence specificity and catalytic properties of furin. Proc. Natl. Acad. Sci. USA 89, 10277–10281 (1992).

4. Molloy, S.S., Bresnahan, P.A., Leppla, S.H., Klimpel, K.R. & Thomas, G. Human furin is a calcium-dependent serine endoprotease that recognizes the sequence Arg-X-X-Arg and efficiently cleaves anthrax toxin protective antigen. J. Biol. Chem. 267, 16396–16402 (1992).

5. Leppla, S.H. Anthrax toxin edema factor: a bacterial adenylate cyclase that increases cyclic AMP concentrations of eukaryotic cells. Proc. Natl. Acad. Sci. USA 79, 3162–3166 (1982).

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