The Akt activation inhibitor TCN-P inhibits Akt phosphorylation by binding to the PH domain of Akt and blocking its recruitment to the plasma membrane-Reference-Cited by-同舟云学术

The Akt activation inhibitor TCN-P inhibits Akt phosphorylation by binding to the PH domain of Akt and blocking its recruitment to the plasma membrane

Published:2010-05-21 Issue:11 Volume:17 Page:1795-1804
ISSN:1350-9047
Container-title:Cell Death & Differentiation
language:en
Short-container-title:Cell Death Differ

Author:

Berndt N,Yang H,Trinczek B,Betzi S,Zhang Z,Wu B,Lawrence N J,Pellecchia M,Schönbrunn E,Cheng J Q,Sebti S M

Publisher

Springer Science and Business Media LLC

Subject

Cell Biology,Molecular Biology

Link

http://www.nature.com/articles/cdd201063.pdf

Reference41 articles.

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2. Coffer PJ, Woodgett JR . Molecular cloning and characterisation of a novel putative protein-serine kinase related to the cAMP-dependent and protein kinase C families. Eur J Biochem 1991; 201: 475–481.

3. Bellacosa A, Testa HR, Staal SP, Tsichlis PN . A retroviral oncogene, akt, encoding a serine-threonine kinase containing an SH2-like region. Science 1991; 254: 274–277.

4. Manning BD, Cantley LC . AKT/PKB signaling: navigating downstream. Cell 2007; 129: 1261–1274.

5. Qiao M, Sheng S, Pardee AB . Metastasis and AKT activation. Cell Cycle 2008; 7: 2991–2996.

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