How are cell and tissue structure and function influenced by gravity and what are the gravity perception mechanisms?
-
Published:2024-02-10
Issue:1
Volume:10
Page:
-
ISSN:2373-8065
-
Container-title:npj Microgravity
-
language:en
-
Short-container-title:npj Microgravity
Author:
Davis TrentORCID, Tabury KevinORCID, Zhu Shouan, Angeloni Debora, Baatout SarahORCID, Benchoua Alexandra, Bereiter-Hahn Juergen, Bottai DanieleORCID, Buchheim Judith-Irina, Calvaruso Marco, Carnero-Diaz Eugénie, Castiglioni Sara, Cavalieri DuccioORCID, Ceccarelli Gabriele, Choukér AlexanderORCID, Cialdai Francesca, Ciofani GianniORCID, Coppola Giuseppe, Cusella Gabriella, Degl’Innocenti Andrea, Desaphy Jean-FrancoisORCID, Frippiat Jean-PolORCID, Gelinsky MichaelORCID, Genchi Giada, Grano Maria, Grimm DanielaORCID, Guignandon Alain, Hahn Christiane, Hatton Jason, Herranz RaúlORCID, Hellweg Christine E.ORCID, Iorio Carlo Saverio, Karapantsios ThodorisORCID, van Loon Jack J.W.A.ORCID, Lulli MatteoORCID, Maier Jeanette, Malda Jos, Mamaca Emina, Morbidelli Lucia, van Ombergen Angelique, Osterman Andreas, Ovsianikov AleksandrORCID, Pampaloni FrancescoORCID, Pavezlorie Elizabeth, Pereda-Campos Veronica, Przybyla Cyrille, Puhl Christopher, Rettberg PetraORCID, Rizzo Angela MariaORCID, Robson-Brown Kate, Rossi Leonardo, Russo Giorgio, Salvetti Alessandra, Santucci DanielaORCID, Sperl MatthiasORCID, Tavella SaraORCID, Thielemann ChristianeORCID, Willaert RonnieORCID, Szewczyk NathanielORCID, Monici MonicaORCID
Abstract
AbstractProgress in mechanobiology allowed us to better understand the important role of mechanical forces in the regulation of biological processes. Space research in the field of life sciences clearly showed that gravity plays a crucial role in biological processes. The space environment offers the unique opportunity to carry out experiments without gravity, helping us not only to understand the effects of gravitational alterations on biological systems but also the mechanisms underlying mechanoperception and cell/tissue response to mechanical and gravitational stresses. Despite the progress made so far, for future space exploration programs it is necessary to increase our knowledge on the mechanotransduction processes as well as on the molecular mechanisms underlying microgravity-induced cell and tissue alterations. This white paper reports the suggestions and recommendations of the SciSpacE Science Community for the elaboration of the section of the European Space Agency roadmap “Biology in Space and Analogue Environments” focusing on “How are cells and tissues influenced by gravity and what are the gravity perception mechanisms?” The knowledge gaps that prevent the Science Community from fully answering this question and the activities proposed to fill them are discussed.
Publisher
Springer Science and Business Media LLC
Reference48 articles.
1. Bradbury, P. et al. Modeling the impact of microgravity at the cellular level: implications for human disease. Front. Cell Dev. Biol. 8, 96 (2020). 2. Vandenburgh, H. H. Mechanical forces and their second messengers in stimulating cell growth in vitro. Am. J. Physiol. 262, R350–R355 (1992). 3. Unsworth, B. R. & Lelkes, P. I. Growing tissues in microgravity. Nat. Med. 4, 901–907 (1998). 4. Imura, T., Otsuka, T., Kawahara, Y. & Yuge, L. “Microgravity” as a unique and useful stem cell culture environment for cell-based therapy. Regen. Ther. 12, 2–5 (2019). 5. Morbidelli, L. et al. Simulated hypogravity impairs the angiogenic response of endothelium by up-regulating apoptotic signals. Biochem. Biophys. Res. Commun. 334, 491–499 (2005).
|
|