Abstract
AbstractWith increased human presence in space, bone loss and fractures will occur. Thrombopoietin (TPO) is a recently patented bone healing agent. Here, we investigated the systemic effects of TPO on mice subjected to spaceflight and sustaining a bone fracture. Forty, 9-week-old, male, C57BL/6 J were divided into 4 groups: (1) Saline+Earth; (2) TPO + Earth; (3) Saline+Flight; and (4) TPO + Flight (n = 10/group). Saline- and TPO-treated mice underwent a femoral defect surgery, and 20 mice were housed in space (“Flight”) and 20 mice on Earth for approximately 4 weeks. With the exception of the calvarium and incisor, positive changes were observed in TPO-treated, spaceflight bones, suggesting TPO may improve osteogenesis in the absence of mechanical loading. Thus, TPO, may serve as a new bone healing agent, and may also improve some skeletal properties of astronauts, which might be extrapolated for patients on Earth with restraint mobilization and/or are incapable of bearing weight on their bones.
Publisher
Springer Science and Business Media LLC
Subject
Space and Planetary Science,Physics and Astronomy (miscellaneous),Agricultural and Biological Sciences (miscellaneous),Biochemistry, Genetics and Molecular Biology (miscellaneous),Materials Science (miscellaneous),Medicine (miscellaneous)
Reference67 articles.
1. Fernholz, T. Rocket Billionaires: Elon Musk, Jeff Bezos, and the New Space Race. Ch. 2 (Houghton Mifflin Harcourt, 2018).
2. Honeycutt, J., Cianciola, C. & Wooten, L. NASA’s space launch system: artemis 1 vehicle nears completion. https://ntrs.nasa.gov/citations/20190030450 (2019).
3. Lambright, W. H. NASA, industry, and the commerical crew development program. In NASA Spaceflight: A History of Innovation (eds Launius, R & McCurdy, H.) Ch. 13. (Springer Nature, 2018).
4. Zhao, Y. Oxford Research Encyclopedia of Planetary Science. Ch. 7. (Oxford University Press, 2018).
5. Weinzierl, M. Space, the final economic frontier. J. Econ. Perspect. 32, 173–192 (2018).
Cited by
7 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献