Cross-ancestry meta-analysis of opioid use disorder uncovers novel loci with predominant effects in brain regions associated with addiction

Author:

Kember Rachel L.ORCID,Vickers-Smith Rachel,Xu Heng,Toikumo Sylvanus,Niarchou MariaORCID,Zhou HangORCID,Hartwell Emily E.ORCID,Crist Richard C.,Rentsch Christopher T.ORCID,Davis Lea K.,Justice Amy C.ORCID,Sanchez-Roige SandraORCID,Kampman Kyle M.,Gelernter JoelORCID,Kranzler Henry R.ORCID,

Funder

U.S. Department of Health & Human Services | NIH | National Institute on Alcohol Abuse and Alcoholism

U.S. Department of Veterans Affairs

U.S. Department of Health & Human Services | NIH | National Institute on Drug Abuse

Publisher

Springer Science and Business Media LLC

Subject

General Neuroscience

Reference81 articles.

1. American Psychiatric Association Diagnostic and Statistical Manual of Mental Disorders (American Psychiatric Association, 2013); https://doi.org/10.1176/appi.books.9780890425596

2. Strang, J. et al. Opioid use disorder. Nat. Rev. Dis. Primers 6, 3 (2020).

3. Vowles, K. E. et al. Rates of opioid misuse, abuse, and addiction in chronic pain: a systematic review and data synthesis. Pain 156, 569–576 (2015).

4. Centers for Disease Control and Prevention Vital signs: overdoses of prescription opioid pain relievers and other drugs among women–United States, 1999–2010. MMWR Morb. Mortal. Wkly Rep. 62, 537–542 (2013).

5. Key Substance Use and Mental Health Indicators in the United States: Results from the 2019 National Survey on Drug Use and Health (Substance Abuse and Mental Health Services Administration, 2020); https://www.samhsa.gov/data/sites/default/files/reports/rpt29393/2019NSDUHFFRPDFWHTML/2019NSDUHFFR090120.htm

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