Positron emission tomography and magnetic resonance imaging methods and datasets within the Dominantly Inherited Alzheimer Network (DIAN)
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Published:2023-07-10
Issue:8
Volume:26
Page:1449-1460
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ISSN:1097-6256
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Container-title:Nature Neuroscience
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language:en
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Short-container-title:Nat Neurosci
Author:
McKay Nicole S.ORCID, Gordon Brian A.ORCID, Hornbeck Russ C., Dincer Aylin, Flores ShaneyORCID, Keefe Sarah J., Joseph-Mathurin NellyORCID, Jack Clifford R.ORCID, Koeppe Robert, Millar Peter R.ORCID, Ances Beau M., Chen Charles D.ORCID, Daniels Alisha, Hobbs Diana A.ORCID, Jackson Kelley, Koudelis Deborah, Massoumzadeh Parinaz, McCullough Austin, Nickels Michael L., Rahmani Farzaneh, Swisher Laura, Wang Qing, Allegri Ricardo F.ORCID, Berman Sarah B., Brickman Adam M., Brooks William S.ORCID, Cash David M.ORCID, Chhatwal Jasmeer P.ORCID, Day Gregory S.ORCID, Farlow Martin R., la Fougère ChristianORCID, Fox Nick C., Fulham MichaelORCID, Ghetti BernardinoORCID, Graff-Radford Neill, Ikeuchi TakeshiORCID, Klunk William, Lee Jae-Hong, Levin Johannes, Martins Ralph, Masters Colin L., McConathy Jonathan, Mori Hiroshi, Noble James M., Reischl Gerald, Rowe Christopher, Salloway StephenORCID, Sanchez-Valle Raquel, Schofield Peter R.ORCID, Shimada Hiroyuki, Shoji Mikio, Su YiORCID, Suzuki Kazushi, Vöglein JonathanORCID, Yakushev Igor, Cruchaga CarlosORCID, Hassenstab Jason, Karch CelesteORCID, McDade EricORCID, Perrin Richard J.ORCID, Xiong Chengjie, Morris John C., Bateman Randall J.ORCID, Benzinger Tammie L. S.ORCID, Brickman Adam. M., la Fougère Christian,
Abstract
AbstractThe Dominantly Inherited Alzheimer Network (DIAN) is an international collaboration studying autosomal dominant Alzheimer disease (ADAD). ADAD arises from mutations occurring in three genes. Offspring from ADAD families have a 50% chance of inheriting their familial mutation, so non-carrier siblings can be recruited for comparisons in case–control studies. The age of onset in ADAD is highly predictable within families, allowing researchers to estimate an individual’s point in the disease trajectory. These characteristics allow candidate AD biomarker measurements to be reliably mapped during the preclinical phase. Although ADAD represents a small proportion of AD cases, understanding neuroimaging-based changes that occur during the preclinical period may provide insight into early disease stages of ‘sporadic’ AD also. Additionally, this study provides rich data for research in healthy aging through inclusion of the non-carrier controls. Here we introduce the neuroimaging dataset collected and describe how this resource can be used by a range of researchers.
Publisher
Springer Science and Business Media LLC
Subject
General Neuroscience
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