Abstract
AbstractThis review explores the effect of tiotropium Respimat® add-on therapy on asthma exacerbations and worsenings, adverse events (AEs) related to exacerbations and symptoms and any effects on seasonality across the 10 UniTinA-asthma® clinical trials comprising over 6000 patients. When added on to inhaled corticosteroids ± additional therapies, tiotropium significantly reduced the risk of exacerbations and worsenings in adults with symptomatic severe asthma and provided a non-significant improvement in worsenings in adults with symptomatic moderate and mild asthma, which was significant for patients with moderate asthma receiving tiotropium 2.5 µg once daily vs. placebo. Trials in paediatric patients were not powered to assess exacerbations or worsenings, but when AEs related to asthma exacerbations and symptoms were grouped into a composite endpoint and pooled, tiotropium improved outcomes vs. placebo (rate ratio 0.76; 95% confidence interval 0.63, 0.93). The reduction in exacerbations with tiotropium is apparent across all patients during the observed seasonal peaks of these events.
Publisher
Springer Science and Business Media LLC
Subject
Public Health, Environmental and Occupational Health,Pulmonary and Respiratory Medicine
Reference48 articles.
1. Pavord, I. D. et al. The impact of poor asthma control among asthma patients treated with inhaled corticosteroids plus long-acting beta2-agonists in the United Kingdom: a cross-sectional analysis. NPJ Prim. Care Respir. Med. 27, 17 (2017).
2. Papaioannou, A. I. et al. Control of asthma in real life: still a valuable goal? Eur. Respir. Rev. 24, 361–369 (2015).
3. Global Initiative for Asthma. Global strategy for asthma management and prevention (2020 report). https://ginasthma.org/wp-content/uploads/2020/04/GINA-2020-full-report_-final-_wms.pdf (2020).
4. Camargo, C. A. Jr., Rachelefsky, G. & Schatz, M. Managing asthma exacerbations in the emergency department: summary of the National Asthma Education and Prevention Program Expert Panel Report 3 guidelines for the management of asthma exacerbations. J. Allergy Clin. Immunol. 124, S5–S14 (2009).
5. McKeever, T. et al. Quadrupling inhaled glucocorticoid dose to abort asthma exacerbations. N. Engl. J. Med. 378, 902–910 (2018).
Cited by
5 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献