Colocalized Delivery of Rapamycin and Paclitaxel to Tumors Enhances Synergistic Targeting of the PI3K/Akt/mTOR Pathway

Author:

Blanco Elvin,Sangai Takafumi,Wu Suhong,Hsiao Angela,Ruiz-Esparza Guillermo U,Gonzalez-Delgado Carlos A,Cara Francisca E,Granados-Principal Sergio,Evans Kurt W,Akcakanat Argun,Wang Ying,Do Kim-Anh,Meric-Bernstam Funda,Ferrari Mauro

Funder

CDMRP Department of Defense Breast Cancer Research Program (DOD/BCRP) Innovator Award

National Center for Research Resources NIH

University of Texas MD Anderson Cancer Center

DOD/BCRP

Susan G. Komen Breast Cancer Foundation

Publisher

Elsevier BV

Subject

Drug Discovery,Pharmacology,Genetics,Molecular Biology,Molecular Medicine

Reference50 articles.

1. Multiple roles and therapeutic implications of Akt signaling in cancer;Calvo;Onco Targets Ther,2009

2. New targets for therapy in breast cancer: mammalian target of rapamycin (mTOR) antagonists;Carraway;Breast Cancer Res,2004

3. Targeting the mTOR signaling network for cancer therapy;Meric-Bernstam;J Clin Oncol,2009

4. mTOR signaling and drug development in cancer;Dancey;Nat Rev Clin Oncol,2010

5. Determinants of rapamycin sensitivity in breast cancer cells;Noh;Clin Cancer Res,2004

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