Multimodal deep learning of fundus abnormalities and traditional risk factors for cardiovascular risk prediction

Author:

Lee Yeong ChanORCID,Cha Jiho,Shim InjeongORCID,Park Woong-Yang,Kang Se Woong,Lim Dong Hui,Won Hong-HeeORCID

Abstract

AbstractCardiovascular disease (CVD), the leading cause of death globally, is associated with complicated underlying risk factors. We develop an artificial intelligence model to identify CVD using multimodal data, including clinical risk factors and fundus photographs from the Samsung Medical Center (SMC) for development and internal validation and from the UK Biobank for external validation. The multimodal model achieves an area under the receiver operating characteristic curve (AUROC) of 0.781 (95% confidence interval [CI] 0.766–0.798) in the SMC and 0.872 (95% CI 0.857–0.886) in the UK Biobank. We further observe a significant association between the incidence of CVD and the predicted risk from at-risk patients in the UK Biobank (hazard ratio [HR] 6.28, 95% CI 4.72–8.34). We visualize the importance of individual features in photography and traditional risk factors. The results highlight that non-invasive fundus photography can be a possible predictive marker for CVD.

Funder

National Research Foundation of Korea

Publisher

Springer Science and Business Media LLC

Subject

Health Information Management,Health Informatics,Computer Science Applications,Medicine (miscellaneous)

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