The TCR's sensitivity to self peptide–MHC dictates the ability of naive CD8+ T cells to respond to foreign antigens-Reference-Cited by-同舟云学术

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The TCR's sensitivity to self peptide–MHC dictates the ability of naive CD8+ T cells to respond to foreign antigens

Published:2014-11-24 Issue:1 Volume:16 Page:107-117
ISSN:1529-2908
Container-title:Nature Immunology
language:en
Short-container-title:Nat Immunol

Author:

Fulton Ross B,Hamilton Sara E,Xing Yan,Best J Adam,Goldrath Ananda W,Hogquist Kristin A,Jameson Stephen C

Publisher

Springer Science and Business Media LLC

Subject

Immunology,Immunology and Allergy

Link

http://www.nature.com/articles/ni.3043.pdf

Reference56 articles.

1. Zehn, D., Lee, S.Y. & Bevan, M.J. Complete but curtailed T-cell response to very low-affinity antigen. Nature 458, 211–214 (2009).

2. Tubo, N.J. et al. Single naive CD4+ T cells from a diverse repertoire produce different effector cell types during infection. Cell 153, 785–796 (2013).

3. Fazilleau, N., McHeyzer-Williams, L.J., Rosen, H. & McHeyzer-Williams, M.G. The function of follicular helper T cells is regulated by the strength of T cell antigen receptor binding. Nat. Immunol. 10, 375–384 (2009).

4. Plumlee, C.R., Sheridan, B.S., Cicek, B.B. & Lefrancois, L. Environmental cues dictate the fate of individual CD8+ T cells responding to infection. Immunity 39, 347–356 (2013).

5. Dorfman, J.R., Stefanova, I., Yasutomo, K. & Germain, R.N. CD4+ T cell survival is not directly linked to self-MHC-induced TCR signaling. Nat. Immunol. 1, 329–335 (2000).

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