Silencing AML1-ETO gene expression leads to simultaneous activation of both pro-apoptotic and proliferation signaling

Author:

Spirin P V,Lebedev T D,Orlova N N,Gornostaeva A S,Prokofjeva M M,Nikitenko N A,Dmitriev S E,Buzdin A A,Borisov N M,Aliper A M,Garazha A V,Rubtsov P M,Stocking C,Prassolov V S

Publisher

Springer Science and Business Media LLC

Subject

Oncology,Cancer Research,Hematology

Reference37 articles.

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2. Licht JD . AML1 and the AML1-ETO fusion protein in the pathogenesis of t(8;21) AML. Oncogene 2001; 20: 5660–5679.

3. Guerrasio A, Rosso C, Martinelli G, Lo Coco F, Pampinella M, Santoro A et al. Polyclonal haemopoieses associated with long-term persistence of the AML1-ETO transcript in patients with FAB M2 acute myeloid leukaemia in continous clinical remission. Br J Haematol 1995; 90: 364–368.

4. Wang J, Saunthararajah Y, Redner RL, Liu JM . Inhibitors of histone deacetylase relieve ETO-mediated repression and induce differentiation of AML1-ETO leukemia cells. Cancer Res 1999; 59: 2766–2769.

5. Hug BA, Lazar MA . ETO interacting proteins. Oncogene 2004; 23: 4270–4274.

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