BAF complex vulnerabilities in cancer demonstrated via structure-based PROTAC design-Reference-Cited by-同舟云学术

BAF complex vulnerabilities in cancer demonstrated via structure-based PROTAC design

Published:2019-06-10 Issue:7 Volume:15 Page:672-680
ISSN:1552-4450
Container-title:Nature Chemical Biology
language:en
Short-container-title:Nat Chem Biol

Author:

Farnaby William^ORCID,Koegl Manfred,Roy Michael J.^ORCID,Whitworth Claire^ORCID,Diers Emelyne^ORCID,Trainor Nicole,Zollman David,Steurer Steffen,Karolyi-Oezguer Jale,Riedmueller Carina,Gmaschitz Teresa,Wachter Johannes,Dank Christian,Galant Michael,Sharps Bernadette,Rumpel Klaus,Traxler Elisabeth,Gerstberger Thomas,Schnitzer Renate,Petermann Oliver,Greb Peter,Weinstabl Harald,Bader Gerd,Zoephel Andreas,Weiss-Puxbaum Alexander,Ehrenhöfer-Wölfer Katharina^ORCID,Wöhrle Simon^ORCID,Boehmelt Guido,Rinnenthal Joerg,Arnhof Heribert,Wiechens Nicola,Wu Meng-Ying,Owen-Hughes Tom,Ettmayer Peter^ORCID,Pearson Mark,McConnell Darryl B.^ORCID,Ciulli Alessio^ORCID

Publisher

Springer Science and Business Media LLC

Subject

Cell Biology,Molecular Biology

Link

http://www.nature.com/articles/s41589-019-0294-6.pdf

Reference55 articles.

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2. Collins, I., Wang, H., Caldwell, J. J. & Chopra, R. Chemical approaches to targeted protein degradation through modulation of the ubiquitin–proteasome pathway. Biochem. J. 474, 1127–1147 (2017).

3. Hughes, S. J. & Ciulli, A. Molecular recognition of ternary complexes: a new dimension in the structure-guided design of chemical degraders. Essays Biochem. 61, 505–516 (2017).

4. Bondeson, D. P. et al. Catalytic in vivo protein knockdown by small-molecule PROTACs. Nat. Chem. Biol. 11, 611–617 (2015).

5. Winter, G. E. et al. Phthalimide conjugation as a strategy for in vivo target protein degradation. Science 348, 1376–1381 (2015).

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