CRISPR-Cas9 screens identify regulators of antibody–drug conjugate toxicity-Reference-Cited by-同舟云学术

CRISPR-Cas9 screens identify regulators of antibody–drug conjugate toxicity

Published:2019-08-26 Issue:10 Volume:15 Page:949-958
ISSN:1552-4450
Container-title:Nature Chemical Biology
language:en
Short-container-title:Nat Chem Biol

Author:

Tsui C. Kimberly^ORCID,Barfield Robyn M.,Fischer Curt R.^ORCID,Morgens David W.,Li Amy,Smith Benjamin A. H.^ORCID,Gray Melissa Anne,Bertozzi Carolyn R.,Rabuka David,Bassik Michael C.^ORCID

Publisher

Springer Science and Business Media LLC

Subject

Cell Biology,Molecular Biology

Link

http://www.nature.com/articles/s41589-019-0342-2.pdf

Reference51 articles.

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2. Lyon, R. Drawing lessons from the clinical development of antibody-drug conjugates. Drug Discov. Today Technol. 30, 105–109 (2018).

3. St Pierre, C. A., Leonard, D., Corvera, S., Kurt-Jones, E. A. & Finberg, R. W. Antibodies to cell surface proteins redirect intracellular trafficking pathways. Exp. Mol. Pathol. 91, 723–732 (2011).

4. Ritchie, M., Tchistiakova, L. & Scott, N. Implications of receptor-mediated endocytosis and intracellular trafficking dynamics in the development of antibody drug conjugates. MAbs 5, 13–21 (2013).

5. Loganzo, F. et al. Tumor cells chronically treated with a trastuzumab-maytansinoid antibody-drug conjugate develop varied resistance mechanisms but respond to alternate treatments. Mol. Cancer Ther. 14, 952–963 (2015).

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