A small-molecule activation mechanism that directly opens the KCNQ2 channel-Reference-Cited by-同舟云学术

A small-molecule activation mechanism that directly opens the KCNQ2 channel

Published:2024-01-02 Issue:7 Volume:20 Page:847-856
ISSN:1552-4450
Container-title:Nature Chemical Biology
language:en
Short-container-title:Nat Chem Biol

Author:

Zhang Shaoying,Ma Demin^ORCID,Wang Kun,Li Ya,Yang Zhenni,Li Xiaoxiao,Li Junnan,He Jiangnan,Mei Lianghe,Ye Yangliang,Chen Zongsheng,Shen Juwen,Hou Panpan,Guo Jiangtao^ORCID,Zhang Qiansen^ORCID,Yang Huaiyu^ORCID

Publisher

Springer Science and Business Media LLC

Link

https://www.nature.com/articles/s41589-023-01515-y.pdf

Reference72 articles.

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3. Schewe, M. et al. A pharmacological master key mechanism that unlocks the selectivity filter gate in K+ channels. Science 363, 875–880 (2019).

4. Wulff, H. & Zhorov, B. S. K+ Channel modulators for the treatment of neurological disorders and autoimmune diseases. Chem. Rev. 108, 1744–1773 (2008).

5. Wulff, H., Castle, N. A. & Pardo, L. A. Voltage-gated potassium channels as therapeutic targets. Nat. Rev. Drug Discov. 8, 982–1001 (2009).

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