Structure of GPR101–Gs enables identification of ligands with rejuvenating potential
Author:
Publisher
Springer Science and Business Media LLC
Subject
Cell Biology,Molecular Biology
Link
https://www.nature.com/articles/s41589-023-01456-6.pdf
Reference49 articles.
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3. Xiao, X. et al. A new understanding of GHSR1a—independent of ghrelin activation. Ageing Res Rev. 64, 101187 (2020).
4. Tao, Y. X. Constitutive activation of G protein-coupled receptors and diseases: insights into mechanisms of activation and therapeutics. Pharmacol. Ther. 120, 129–148 (2008).
5. Bond, R. A. & Ijzerman, A. P. Recent developments in constitutive receptor activity and inverse agonism, and their potential for GPCR drug discovery. Trends Pharmacol. Sci. 27, 92–96 (2006).
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