Characterizing the metabolomes of phase-separated condensates
Author:
Publisher
Springer Science and Business Media LLC
Subject
Cell Biology,Molecular Biology
Link
https://www.nature.com/articles/s41589-023-01487-z.pdf
Reference5 articles.
1. Hirose, T., Ninomiya, K., Nakagawa, S. & Yamazaki, T. A guide to membraneless organelles and their various roles in gene regulation. Nat. Rev. Mol. Cell. Biol. 24, 288–304 (2023). This review discusses the biological processes associated with gene regulation that occur within condensates.
2. Boronenkov, I. V., Loijens, J. C., Umeda, M. & Anderson, R. A. Phosphoinositide signaling pathways in nuclei are associated with nuclear speckles containing pre-mRNA processing factors. MBoC 9, 3547–3560 (1998). This paper identifies phosphoinositides and phosphoinositide-modifying proteins in nuclear speckles.
3. Klein, I. A. et al. Partitioning of cancer therapeutics in nuclear condensates. Science 368, 1386 (2020). This paper demonstrates that a small-molecule chemotherapeutic can partition into a mediator of RNA polymerase II transcription subunit 1 (MED1)-containing condensates.
4. Martin, E. W. & Mittag, T. Relationship of sequence and phase separation in protein low-complexity regions. Biochemistry 57, 2478–2487 (2018). This article highlights how different sequences in low-complexity regions can affect phase separation.
5. Milkovic, N. M. & Mittag, T. in Intrinsically Disordered Proteins: Methods and Protocols 1st edn, Vol. 2141 (eds. Kragelund, B. B. & Skriver, K.) 685–702 (Humana, 2020). This paper provides a general method for the separation of condensates by centrifugation.
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