Lipid metabolism in T cell signaling and function
Author:
Funder
U.S. Department of Health & Human Services | National Institutes of Health
Publisher
Springer Science and Business Media LLC
Subject
Cell Biology,Molecular Biology
Link
https://www.nature.com/articles/s41589-022-01017-3.pdf
Reference100 articles.
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3. Trompette, A. et al. Dietary fiber confers protection against flu by shaping Ly6c− patrolling monocyte hematopoiesis and CD8+ T cell metabolism. Immunity 48, 992–1005 e1008 (2018).
4. Bachem, A. et al. Microbiota-derived short-chain fatty acids promote the memory potential of antigen-activated CD8+ T cells. Immunity 51, 285–297.e285 (2019).
5. Dudek, M. et al. Auto-aggressive CXCR6+ CD8 T cells cause liver immune pathology in NASH. Nature 592, 444–449 (2021). This paper shows a pathogenic role for the SCFA acetate in CD8+ T cell-mediated autoinflammation and tissue damage in the liver, which is in contrast to the protective roles of SCFAs in tissue homeostasis or anti-pathogen immunity.
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