Live-cell target engagement of allosteric MEKi on MEK–RAF/KSR–14-3-3 complexes
Author:
Funder
U.S. Department of Health & Human Services | NIH | National Cancer Institute
Publisher
Springer Science and Business Media LLC
Subject
Cell Biology,Molecular Biology
Link
https://www.nature.com/articles/s41589-023-01454-8.pdf
Reference47 articles.
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2. Yaeger, R. & Corcoran, R. B. Targeting alterations in the RAF–MEK pathway. Cancer Discov. 9, 329–341 (2019).
3. Prior, I. A., Hood, F. E. & Hartley, J. L. The frequency of RAS mutations in cancer. Cancer Res. 80, 2969–2974 (2020).
4. Simanshu, D. K., Nissley, D. V. & McCormick, F. RAS proteins and their regulators in human disease. Cell 170, 17–33 (2017).
5. Lavoie, H. & Therrien, M. Regulation of RAF protein kinases in ERK signalling. Nat. Rev. Mol. Cell Biol. 16, 281–298 (2015).
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