Dynamic modulation of enzyme activity by synthetic CRISPR–Cas6 endonucleases
Author:
Funder
National Science Foundation
Publisher
Springer Science and Business Media LLC
Subject
Cell Biology,Molecular Biology
Link
https://www.nature.com/articles/s41589-022-01005-7.pdf
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3. Westfall, P. J. et al. Production of amorphadiene in yeast, and its conversion to dihydroartemisinic acid, precursor to the antimalarial agent artemisinin. Proc. Natl Acad. Sci. USA 109, E111–E118 (2012).
4. Pitera, D. J., Paddon, C. J., Newman, J. D. & Keasling, J. D. Balancing a heterologous mevalonate pathway for improved isoprenoid production in Escherichia coli. Metab. Eng. 9, 193–207 (2007).
5. Li, N., Zeng, W., Xu, S. & Zhou, J. Toward fine-tuned metabolic networks in industrial microorganisms. Synth. Syst. Biotechnol. 5, 81–91 (2020).
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