Bridge helix arginines play a critical role in Cas9 sensitivity to mismatches-Reference-Cited by-同舟云学术

Bridge helix arginines play a critical role in Cas9 sensitivity to mismatches

Published:2020-03-02 Issue:5 Volume:16 Page:587-595
ISSN:1552-4450
Container-title:Nature Chemical Biology
language:en
Short-container-title:Nat Chem Biol

Author:

Bratovič Majda,Fonfara Ines,Chylinski Krzysztof,Gálvez Eric J. C.,Sullivan Timothy J.,Boerno Stefan,Timmermann Bernd,Boettcher Michael^ORCID,Charpentier Emmanuelle^ORCID

Funder

Max-Planck-Gesellschaft

Helmholtz Association

Alexander von Humboldt-Stiftung

Göran Gustafssons Stiftelse för Naturvetenskaplig och Medicinsk Forskning

Kempestiftelserna

Umeå Universitet

Svenska Forskningsrådet Formas

Max Planck Foundation

Publisher

Springer Science and Business Media LLC

Subject

Cell Biology,Molecular Biology

Link

http://www.nature.com/articles/s41589-020-0490-4.pdf

Reference50 articles.

1. Gasiunas, G., Barrangou, R., Horvath, P. & Siksnys, V. Cas9–crRNA ribonucleoprotein complex mediates specific DNA cleavage for adaptive immunity in bacteria. Proc. Natl Acad. Sci. USA 109, E2579–E2586 (2012).

2. Jinek, M. et al. A programmable dual-RNA–Guided DNA endonuclease in adaptive bacterial immunity. Science 337, 816–821 (2012).

3. Deltcheva, E. et al. CRISPR RNA maturation by trans-encoded small RNA and host factor RNase III. Nature 471, 602 (2011).

4. Sternberg, S. H., Redding, S., Jinek, M., Greene, E. C. & Doudna, J. A. DNA interrogation by the CRISPR RNA-guided endonuclease Cas9. Nature 507, 62 (2014).

5. Szczelkun, M. D. et al. Direct observation of R-loop formation by single RNA-guided Cas9 and cascade effector complexes. Proc. Natl Acad. Sci. USA 111, 9798–9803 (2014).

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