The morphogen Sonic hedgehog inhibits its receptor Patched by a pincer grasp mechanism
Author:
Publisher
Springer Science and Business Media LLC
Subject
Cell Biology,Molecular Biology
Link
http://www.nature.com/articles/s41589-019-0370-y.pdf
Reference51 articles.
1. Kong, J. H., Siebold, C. & Rohatgi, R. Biochemical mechanisms of vertebrate hedgehog signaling Development 146, dev166892 (2019).
2. Porter, J. A., Young, K. E. & Beachy, P. A. Cholesterol modification of hedgehog signaling proteins in animal development. Science 274, 255–259 (1996).
3. Pepinsky, R. B. et al. Identification of a palmitic acid-modified form of human Sonic hedgehog. J. Biol. Chem. 273, 14037–14045 (1998).
4. Luchetti, G. et al. Cholesterol activates the G-protein coupled receptor Smoothened to promote morphogenetic signaling. Elife 5, 20304 (2016).
5. Huang, P. et al. Cellular cholesterol directly activates smoothened in Hedgehog signaling. Cell 166, 1176–1187 e1114 (2016).
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