Bi-paratopic and multivalent VH domains block ACE2 binding and neutralize SARS-CoV-2
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Published:2020-10-20
Issue:1
Volume:17
Page:113-121
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ISSN:1552-4450
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Container-title:Nature Chemical Biology
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language:en
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Short-container-title:Nat Chem Biol
Author:
Bracken Colton J.ORCID, Lim Shion A.ORCID, Solomon Paige, Rettko Nicholas J.ORCID, Nguyen Duy P., Zha Beth Shoshana, Schaefer Kaitlin, Byrnes James R.ORCID, Zhou Jie, Lui IreneORCID, Liu Jia, Pance Katarina, Azumaya Caleigh M., Braxton Julian R., Brilot Axel F., Gupta Meghna, Li Fei, Lopez Kyle E., Melo Arthur, Merz Gregory E., Moss Frank, Paulino Joana, Pospiech Thomas H., Pourmal Sergei, Puchades Cristina, Rizo Alexandrea N., Smith Amber M., Sun Ming, Thomas Paul V., Wang Feng, Yu Zanlin, Asarnow Daniel, Braxton Julian R., Campbell Melody G., Chio Cynthia M., Chio Un Seng, Dickinson Miles Sasha, Diwanji Devan, Faust Bryan, Gupta Meghna, Hoppe Nick, Jin Mingliang, Li Fei, Li Junrui, Liu Yanxin, Merz Gregory E., Nguyen Henry C., Paulino Joana, Pospiech Thomas H., Pourmal Sergei, Sangwan Smriti, Trenker Raphael, Trinidad Donovan, Tse Eric, Zhang Kaihua, Zhou Fengbo, Azumaya Caleigh M., Billesboelle Christian, Bowen Alisa, Campbell Melody G., Diwanji Devan, Hoppe Nick, Li Yen-Li, Nguyen Phuong, Nowotny Carlos, Puchades Cristina, Safari Mali, Sangwan Smriti, Schaefer Kaitlin, Smith Amber M., Trenker Raphael, Tsui Tsz Kin Martin, Whitis Natalie, Zhao Jianhua, Asarnow Daniel, Azumaya Caleigh M., Chio Cynthia M., Faust Bryan, Gupta Meghna, Kim Kate, Moritz Michelle, Owens Tristan W., Paulino Joana, Peters Jessica K., Pourmal Sergei, Schaefer Kaitlin, Tsui Tsz Kin Martin, Biel Justin, Deshpande Ishan, Herrera Nadia, Kratochvil Huong T., Liu Xi, Schulze-Gahmen Ursula, Young Iris D., Chen Jen, Diallo Amy, Doan Loan, Flores Sebastian, Gupta Meghna, Jin Mingliang, Kratochvil Huong T., Lam Victor L., Li Yang, Lo Megan, Merz Gregory E., Paulino Joana, Thwin Aye C., Titus Erron W., Yu Zanlin, Zhou Fengbo, Zhang Yang, Bulkley David, Joves Arceli, Joves Almarie, McKay Liam, Tabios Mariano, Tse Eric, Agard David A., Cheng Yifan, Fraser James S., Frost Adam, Jura Natalia, Kortemme Tanja, Krogan Nevan J., Manglik Aashish, Rosenberg Oren S., Southworth Daniel R., Stroud Robert M., Verba Kliment A., Zhou Xin X., Leung Kevin K.ORCID, Wells James A.ORCID, , , , , , , , ,
Funder
Helen Hay Whitney Foundation National Science Foundation Damon Runyon Cancer Research Foundation U.S. Department of Health & Human Services | NIH | National Cancer Institute United States Department of Defense | Defense Advanced Research Projects Agency Quantitative Biosciences Institute FastGrants COVID19 grant Laboratory For Genomics Research Chan-Zuckerberg Biohub UCSF Program for Breakthrough Biomedical Research Fast Grants from Emergent Ventures at the Mercatus Center, George Mason University (#2154) The Harrington Discovery Institute
Publisher
Springer Science and Business Media LLC
Subject
Cell Biology,Molecular Biology
Reference55 articles.
1. Yan, R. et al. Structural basis for the recognition of SARS-CoV-2 by full-length human ACE2. Science 367, 1444–1448 (2020). 2. Abraham, J. Passive antibody therapy in COVID-19. Nat. Rev. Immunol. 20, 401–403 (2020). 3. Robbiani, D. F. et al. Convergent antibody responses to SARS-CoV-2 in convalescent individuals. Nature 584, 437–442 (2020). 4. Pinto, D. et al. Cross-neutralization of SARS-CoV-2 by a human monoclonal SARS-CoV antibody. Nature 583, 290–295 (2020). 5. Rogers, T. F. et al. Isolation of potent SARS-CoV-2 neutralizing antibodies and protection from disease in a small animal model. Science 7520, eabc7520 (2020).
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