Structural insights into binding specificity, efficacy and bias of a β2AR partial agonist-Reference-Cited by-同舟云学术

Structural insights into binding specificity, efficacy and bias of a β2AR partial agonist

Published:2018-10-16 Issue:11 Volume:14 Page:1059-1066
ISSN:1552-4450
Container-title:Nature Chemical Biology
language:en
Short-container-title:Nat Chem Biol

Author:

Masureel Matthieu,Zou Yaozhong,Picard Louis-Philippe,van der Westhuizen Emma^ORCID,Mahoney Jacob P.,Rodrigues João P. G. L. M.,Mildorf Thomas J.,Dror Ron O.,Shaw David E.,Bouvier Michel^ORCID,Pardon Els,Steyaert Jan,Sunahara Roger K.^ORCID,Weis William I.,Zhang Cheng^ORCID,Kobilka Brian K.

Publisher

Springer Science and Business Media LLC

Subject

Cell Biology,Molecular Biology

Link

http://www.nature.com/articles/s41589-018-0145-x.pdf

Reference57 articles.

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3. Cazzola, M. & Donner, C. F. Long-acting β2 agonists in the management of stable chronic obstructive pulmonary disease. Drugs 60, 307–320 (2000).

4. Baker, J. G., Proudman, R. G. & Hill, S. J. Salmeterol’s extreme β2 selectivity is due to residues in both extracellular loops and transmembrane domains. Mol. Pharmacol. 87, 103–120 (2015).

5. Ferguson, G. T., Funck-Brentano, C., Fischer, T., Darken, P. & Reisner, C. Cardiovascular safety of salmeterol in COPD. Chest 123, 1817–1824 (2003).

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