Supraphysiological doses of levothyroxine alter regional cerebral metabolism and improve mood in bipolar depression

Author:

Bauer M,London E D,Rasgon N,Berman S M,Frye M A,Altshuler L L,Mandelkern M A,Bramen J,Voytek B,Woods R,Mazziotta J C,Whybrow P C

Publisher

Springer Science and Business Media LLC

Subject

Cellular and Molecular Neuroscience,Psychiatry and Mental health,Molecular Biology

Reference73 articles.

1. Post RM, Frye MA, Denicoff KD, Leverich GS, Kimbrell TA, Dunn RT . Beyond lithium in the treatment of bipolar illness. Neuropsychopharmacology 1998; 19: 206–219.

2. American Psychiatric Association. Practice Guideline for the Treatment of Patients with Bipolar Disorder, 2nd ed. American Psychiatric Publishing, Inc: Washington, DC, 2002.

3. Stancer HC, Persad E . Treatment of intractable rapid-cycling manic-depressive disorder with levothyroxine. Arch Gen Psychiatry 1982; 39: 311–312.

4. Bauer MS, Whybrow PC . Rapid cycling bipolar affective disorders. II. Treatment of refractory rapid cycling with high-dose levothyroxine: a preliminary study. Arch Gen Psychiatry 1990; 47: 435–440.

5. Afflelou S, Auriacombe M, Cazenave M, Chartres JP, Tignol J . Administration of high dose levothyroxine in treatment of rapid cycling bipolar disorders. Review of the literature and initial therapeutic application apropos of 6 cases [Article in French]. Encephale 1997; 23: 209–217.

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