DNA repair dysregulation from cancer driver to therapeutic target
Author:
Publisher
Springer Science and Business Media LLC
Subject
General Earth and Planetary Sciences,General Environmental Science
Link
http://www.nature.com/articles/nrc3399.pdf
Reference197 articles.
1. Hanahan, D. & Weinberg, R. A. Hallmarks of cancer: the next generation. Cell 144, 646–674 (2011). An excellent review highlighting enabling characteristics, as well as emerging hallmarks, of cancer.
2. Bartkova, J. et al. DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis. Nature 434, 864–870 (2005).
3. Gorgoulis, V. G. et al. Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions. Nature 434, 907–913 (2005) References 2 and 3 show that early in tumorigenesis oncogenic stress activates the DDR, which acts as a temporary barrier to progression, but defects in the DDR eventually arise allowing full-blown cancer to develop.
4. Tubbs, J. L., Pegg, A. E. & Tainer, J. A. DNA binding, nucleotide flipping, and the helix-turn-helix motif in base repair by O6-alkylguanine-DNA alkyltransferase and its implications for cancer chemotherapy. DNA Repair 6, 1100–1115 (2007).
5. Tricker, A. R. & Preussmann, R. Carcinogenic N-nitrosamines in the diet: occurrence, formation, mechanisms and carcinogenic potential. Mutat. Res. 259, 277–289 (1991).
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