Targeting the CNS to treat type 2 diabetes
Author:
Publisher
Springer Science and Business Media LLC
Subject
Drug Discovery,Pharmacology,General Medicine
Link
http://www.nature.com/articles/nrd2874.pdf
Reference155 articles.
1. Unger, R. H. The milieu interieur and the islets of Langerhans. Diabetologia 20, 1–11 (1981).
2. Bernard, C. Leçons de physiologie expérimentale appliqués à la médecine (Eds Baillère et Fils, Paris, 1854). Claude Bernard's thesis in 1854 introduced the idea that glucose levels were regulated by CNS actions at the liver (the source of glucose) and at the skeletal muscle (a consumer of glucose).
3. Sandoval, D. A. & Davis, S. N. Metabolic consequences of exercise-associated autonomic failure. Exerc. Sport Sci. Rev. 34, 72–76 (2006).
4. Biggers, D. W. et al. Role of brain in counterregulation of insulin-induced hypoglycemia in dogs. Diabetes 38, 7–16 (1989).
5. Lam, T. K., Gutierrez-Juarez, R., Pocai, A. & Rossetti, L. Regulation of blood glucose by hypothalamic pyruvate metabolism. Science 309, 943–947 (2005). This article showed that the CNS, specifically the mediobasal hypothalamus, responds to increased glucose availability to regulate hepatic glucose production.
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