Conformation-locking antibodies for the discovery and characterization of KRAS inhibitors-Reference-Cited by-同舟云学术

Conformation-locking antibodies for the discovery and characterization of KRAS inhibitors

Published:2022-01-06 Issue:5 Volume:40 Page:769-778
ISSN:1087-0156
Container-title:Nature Biotechnology
language:en
Short-container-title:Nat Biotechnol

Author:

Davies Christopher W.,Oh Angela J.,Mroue Rana,Steffek Micah,Bruning John M.,Xiao Yang,Feng Siyu,Jayakar Sangeeta,Chan Emily,Arumugam Vidhyalakshmi,Uribe Sean Carlo,Drummond Jake,Frommlet Alexandra,Lu Cheng,Franke Yvonne,Merchant Mark,Koeppen Hartmut,Quinn John G.,Malhotra Sushant,Do Steve,Gazzard Lewis,Purkey Hans E.^ORCID,Rudolph Joachim^ORCID,Mulvihill Melinda M.,Koerber James T.^ORCID,Wang Weiru,Evangelista Marie^ORCID

Publisher

Springer Science and Business Media LLC

Subject

Biomedical Engineering,Molecular Medicine,Applied Microbiology and Biotechnology,Bioengineering,Biotechnology

Link

https://www.nature.com/articles/s41587-021-01126-9.pdf

Reference46 articles.

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2. Gao, J., Sidhu, S. S. & Wells, J. A. Two-state selection of conformation-specific antibodies. Proc. Natl Acad. Sci. USA 106, 3071–3076 (2009).

3. Tanaka, T., Williams, R. L. & Rabbitts, T. H. Tumour prevention by a single antibody domain targeting the interaction of signal transduction proteins with RAS. EMBO J. 26, 3250–3259 (2007).

4. McMahon, C. et al. Yeast surface display platform for rapid discovery of conformationally selective nanobodies. Nat. Struct. Mol. Biol. 25, 289–296 (2018).

5. Lightwood, D. J. et al. A conformation-selective monoclonal antibody against a small molecule-stabilised signalling-deficient form of TNF. Nat. Commun. 12, 583 (2021).

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