MHC class II tetramers engineered for enhanced binding to CD4 improve detection of antigen-specific T cells-Reference-Cited by-同舟云学术

MHC class II tetramers engineered for enhanced binding to CD4 improve detection of antigen-specific T cells

Published:2021-05-03 Issue:8 Volume:39 Page:943-948
ISSN:1087-0156
Container-title:Nature Biotechnology
language:en
Short-container-title:Nat Biotechnol

Author:

Dileepan Thamotharampillai^ORCID,Malhotra Deepali^ORCID,Kotov Dmitri I.^ORCID,Kolawole Elizabeth M.^ORCID,Krueger Peter D.,Evavold Brian D.,Jenkins Marc K.^ORCID

Funder

U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases

Publisher

Springer Science and Business Media LLC

Subject

Biomedical Engineering,Molecular Medicine,Applied Microbiology and Biotechnology,Bioengineering,Biotechnology

Link

https://www.nature.com/articles/s41587-021-00893-9.pdf

Reference29 articles.

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2. Jonsson, P. et al. Remarkably low affinity of CD4/peptide-major histocompatibility complex class II protein interactions. Proc. Natl Acad. Sci. USA 113, 5682–5687 (2016).

3. Martinez, R. J., Andargachew, R., Martinez, H. A. & Evavold, B. D. Low-affinity CD4+ T cells are major responders in the primary immune response. Nat. Commun. 7, 13848 (2016).

4. Davis, M. M. T cell receptor gene diversity and selection. Annu. Rev. Biochem. 59, 475–496 (1990).

5. Rudolph, M. G., Stanfield, R. L. & Wilson, I. A. How TCRs bind MHCs, peptides, and coreceptors. Annu. Rev. Immunol. 24, 419–466 (2006).

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