Cholesterol-functionalized DNA/RNA heteroduplexes cross the blood–brain barrier and knock down genes in the rodent CNS-Reference-Cited by-同舟云学术

Cholesterol-functionalized DNA/RNA heteroduplexes cross the blood–brain barrier and knock down genes in the rodent CNS

Published:2021-08-12 Issue:12 Volume:39 Page:1529-1536
ISSN:1087-0156
Container-title:Nature Biotechnology
language:en
Short-container-title:Nat Biotechnol

Author:

Nagata Tetsuya,Dwyer Chrissa A.,Yoshida-Tanaka Kie,Ihara Kensuke,Ohyagi Masaki^ORCID,Kaburagi Hidetoshi,Miyata Haruka,Ebihara Satoe,Yoshioka Kotaro^ORCID,Ishii Takashi,Miyata Kanjiro^ORCID,Miyata Kenichi,Powers Berit,Igari Tomoko,Yamamoto Syunsuke,Arimura Naoto,Hirabayashi Hideki,Uchihara Toshiki,Hara Rintaro Iwata^ORCID,Wada Takeshi,Bennett C. Frank^ORCID,Seth Punit P.,Rigo Frank,Yokota Takanori^ORCID

Funder

Japan Agency for Medical Research and Development

MEXT | Japan Society for the Promotion of Science

MEXT | Japan Science and Technology Agency

Publisher

Springer Science and Business Media LLC

Subject

Biomedical Engineering,Molecular Medicine,Applied Microbiology and Biotechnology,Bioengineering,Biotechnology

Link

https://www.nature.com/articles/s41587-021-00972-x.pdf

Reference54 articles.

1. Kole, R., Krainer, A. R. & Altman, S. RNA therapeutics: beyond RNA interference and antisense oligonucleotides. Nat. Rev. Drug Discov. 11, 125–140 (2012).