An engineered enzyme that targets circulating lactate to alleviate intracellular NADH:NAD+ imbalance-Reference-Cited by-同舟云学术

An engineered enzyme that targets circulating lactate to alleviate intracellular NADH:NAD+ imbalance

Published:2020-01-13 Issue:3 Volume:38 Page:309-313
ISSN:1087-0156
Container-title:Nature Biotechnology
language:en
Short-container-title:Nat Biotechnol

Author:

Patgiri Anupam,Skinner Owen S.,Miyazaki Yusuke,Schleifer Grigorij,Marutani Eizo,Shah Hardik^ORCID,Sharma Rohit,Goodman Russell P.,To Tsz-Leung,Robert Bao Xiaoyan^ORCID,Ichinose Fumito,Zapol Warren M.,Mootha Vamsi K.^ORCID

Funder

Howard Hughes Medical Institute

U.S. Department of Health & Human Services | National Institutes of Health

Marriott Foundation

Publisher

Springer Science and Business Media LLC

Subject

Biomedical Engineering,Molecular Medicine,Applied Microbiology and Biotechnology,Bioengineering,Biotechnology

Link

http://www.nature.com/articles/s41587-019-0377-7.pdf

Reference34 articles.

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3. Titov, D. V. et al. Complementation of mitochondrial electron transport chain by manipulation of the NAD+/NADH ratio. Science 352, 231–235 (2016).

4. Xiao, W. & Loscalzo, J. Metabolic responses to reductive stress. Antioxid. Redox Signal https://doi.org/10.1089/ars.2019.7803 (2019).

5. Gores, G. J. et al. Swelling, reductive stress, and cell death during chemical hypoxia in hepatocytes. Am. J. Physiol. 257, C347–C354 (1989).

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