Measuring SARS-CoV-2 T cell immunity with a scalable qPCR-based assay
Author:
Publisher
Springer Science and Business Media LLC
Subject
Biomedical Engineering,Molecular Medicine,Applied Microbiology and Biotechnology,Bioengineering,Biotechnology
Link
https://www.nature.com/articles/s41587-022-01358-3.pdf
Reference5 articles.
1. Bange, E. M. et al. CD8+ T cells contribute to survival in patients with COVID-19 and hematologic cancer. Nat. Med. 27, 1280–1289 (2021). This paper reports the presence of T cell immunity in patients with cancer and COVID-19 having low or absent antibody responses.
2. Le Bert, N. et al. SARS-CoV-2-specific T cell immunity in cases of COVID-19 and SARS, and uninfected controls. Nature 584, 457–462 (2020). This paper reports the initial description of SARS-CoV-2 specific T cells in patients with COVID-19 and healthy controls.
3. Grifoni, A. et al. Targets of T cell responses to SARS-CoV-2 coronavirus in humans with COVID-19 disease and unexposed individuals. Cell 181, 1489–1501.e1415 (2020). This paper reports the initial demonstration of SARS-CoV-2-specific T cells in patients with COVID-19 and healthy controls.
4. Lozano-Ojalvo, D. et al. Differential effects of the second SARS-CoV-2 mRNA vaccine dose on T cell immunity in naive and COVID-19 recovered individuals. Cell Rep. 36, 109570 (2021). This paper reports that previously infected individuals reach their peak of cellular immunity after one vaccine dose, supporting the notion that natural infection induces T cell immunity.
5. Vardhana, S., Baldo, L., Morice, W. G. 2nd. & Wherry, E. J. Understanding T-cell responses to COVID-19 is essential for informing public health strategies. Sci. Immunol. 7, eabo1303 (2022). A Review article strongly advocating population-level T cell testing.
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