Abstract
AbstractStayGold is an exceptionally bright and stable fluorescent protein that is highly resistant to photobleaching. Despite favorable fluorescence properties, use of StayGold as a fluorescent tag is limited because it forms a natural dimer. Here we report the 1.6 Å structure of StayGold and generate a derivative, mStayGold, that retains the brightness and photostability of the original protein while being fully monomeric.
Funder
RCUK | MRC | Medical Research Foundation
RCUK | Biotechnology and Biological Sciences Research Council
Warwick A*STAR Research Attachment Programme PhD fellowship
DBT India Alliance
DST | Science and Engineering Research Board
Wellcome Trust
Publisher
Springer Science and Business Media LLC
Subject
Biomedical Engineering,Molecular Medicine,Applied Microbiology and Biotechnology,Bioengineering,Biotechnology
Cited by
18 articles.
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